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In this video we explain the concepts for searching DNA to find transcription factor binding sites. This includes a discussion of databases and tools as well as a demonstration of a simple tool…
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In this video we use IGV to visualize DNA-seq data. The demonstration uses date from the ENCODE project as well as BED file made from supplemental data in a published paper.
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This video provides an overview of the ENCODE project and tours through the ENCODE data portal.
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This video has two purposes. First, it is an introduction to the Integrative Genomics Viewer (IGV). Afterwards we demonstrate how IGV can be used to visualize RNA-seq data.
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This video presents an overview of the topics that will be covered in Unit 2 of the BigTap online course.
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This video introduces the GenePattern repository of user friendly bioinformatic tools. Afterwards we use GenePattern to make and visualize hierarchical clusters and heatmaps using trancriptome data.
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This video provides an overview of tools that are available to understand the relationship between your deferentially expressed gene list and biological functions. Within the video are links to…
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This is a demonstration on how to use the desktop version of the the Gene Set Enrichment Analysis (aka GSEA) software to analyze genomics studies. GSEA links biological datasets to genesets of…
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This short video presents the content that will be taught and the skill reinforcing exercises that make up Unit 1 of the BigTap on-line course.
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The purpose of this video is to introduce three tools that can be used to understand candidate genes that are identified in omic analysis: BioGPS, Genecards, and Coremine
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Here we discuss the public databases and repositories that exist for genomic and other omic data. We'll focus on the Gene Expression Omnibus and show how a tool on that site - GEO2R - can be…
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This video examines the special statistical challenges that exist for comparing samples from next generation sequencing (NGS) studies.
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Here we examine the tool of next generation sequencing (NGS) and how it can be used to measure the transcript profile of a biological sample (i.e. RNA-seq). Some basic concepts related to sequencing…
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This is a description of the experiment and paper that we used in our on-line course to demonstrate how to analyze a DNA-Seq study.
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This video discusses the use of next generation sequencing (NGS) to study DNA. It focuses on the concepts important for understanding the protein-DNA interactions that control gene transcription and…
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Here we review some basic statistical principles for defining differences between treatment groups. We extend that to address the statistical challenge that comes from doing thousands of comparisons…
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